Does Zoloft cause Headaches? A Guide to Sertraline Side Effects

Does Zoloft cause headaches? People experience a variety of side effects when taking Zoloft. Some are more common than others, while some are rare and may indicate a serious medical problem.

One of the most common side effects of Zoloft is headaches. Some users may experience frequent headaches while taking this medication, while others may get headaches only occasionally. If you’re taking Zoloft and also have a history of getting headaches that interfere significantly with your day-to-day life, talk to your doctor about what’s causing them.

It’s possible that continuing to take Zoloft will lead to more frequent or severe headaches, which is why it’s important to understand how this medication is interacting with your body and where those interactions are occurring. If you take Zoloft for depression and develop headaches, it can be concerning.

Keep reading to learn more about the connections between Zoloft and headaches as well as tips for managing your symptoms if you experience this side effect. If you’re taking Zoloft for depression, you probably know that it’s a selective serotonin reuptake inhibitor (SSRI). This means it impacts serotonin levels in the brain by reducing their re-release after transmitting a signal to another neuron.

Does Zoloft cause Headaches? A Guide to Sertraline Side Effects

Contents

Can Zoloft Cause Headaches?

Zoloft can cause headaches in more than 1 in 100 people taking it, especially when you first start taking Zoloft, or when you increase the dosage. This is particularly true for those who have migraines triggered by light, smells, or movement. One of the functions of serotonin is to regulate these types of headaches. As a result, when levels of serotonin change as a result of taking Zoloft or similar drugs, some people experience migraines.

It occurs during the first week or two of taking Zoloft or changing the dosage. So if you’ve never experienced anything like this in the past and suddenly start experiencing headaches with your new medication, you might want to discuss it with your doctor.

The side effects go away after the first few weeks of treatment or dose change but if they persist or become a bother (severe), you should see a doctor. As anxiety treatment doctors, we will request you to rest and drink plenty of fluids if you are having headaches caused by sertraline in addition to a painkiller. Moreover, you should not drink too much alcohol. The doctor may also decide to lower the dose to take care of the headaches.

Some people may experience severe headaches while others may be light headaches but in most cases both types are persistent. However, both types of headaches wear off after a few weeks.

Headache is one of the most common side effects of Zoloft. Any of these common headache types might be triggered by taking this drug:

  • Migraine headaches that occur with visual disturbances and nausea.
  • Tension-type headaches that feel like pressure or tightness on both sides of the head.
  • Cluster headaches which are extremely painful and occur in brief attacks during daylight hours.

Migraine headaches where light, smells, or movement can trigger an attack. Whichever type you have, if you take Zoloft or any other drug for depression or anxiety at the same time, you could experience headaches as a side effect.

Tension-type headaches: Zoloft may cause this type of headache.

V migraine headaches that occur with visual disturbances and nausea: Zoloft may cause this type of headache. Cluster headaches that are extremely painful and occur in brief attacks during daylight hours: Zoloft may cause this type of headache.

The tension-type headaches may either become common or severe after you start using sertraline, particularly in the first few weeks of treatment or when you increase the dose. After the body has tolerated the medicine, there is a significant decline in analgesic intake per week.

Whichever type you have, if you take Zoloft or any other drug for depression or anxiety at the same time, you could experience headaches as a side effect. Chronic tension-type headache (CTTH) is the most difficult to treat but can be handled by a decrease in the dosage, taking lots of fluids, resting, and also painkillers.

Cluster headaches: This type of headache may be triggered by Zoloft.

Cluster headaches are extremely painful and occur in brief attacks during daylight hours. They may be triggered by Zoloft. Cluster headaches are classified as one of the types of “primary” headaches, meaning they are not associated with underlying illnesses.

Cluster headaches are typically unilateral (on one side of the head), pulsing or stabbing, and cause severe pain coupled with nausea and vomiting in about one-third of people who have them.

Other symptoms include rhinorrhea and ipsilateral (on the same side) conjunctival injection (redness). Cluster headache episodes can last from 15 minutes to 3 hours and can recur as clusters over weeks or months. The frequency is generally less than once per day for a few days to once every other day for up to 2 years.

Migraine headaches: These may also be caused by taking Zoloft.

There are different types of headaches, but some of the most common and potentially worsened by Zoloft include migraine headaches. These may also be caused by taking Zoloft. One of the most recognizable types of migraine is a classic headache with visual disturbances and nausea (called a V migraine).

Research shows that acute administration of SSRIs in migraineurs which is a common occurrence in depressed people may include the risk of worsening migraine. Zoloft may make the migraines severe or increase the frequency of migraine attacks. If not persistent, the migraines can be treated using triptanes.

Cluster headaches that are extremely painful and occur in brief attacks during daylight hours might also be triggered by taking this drug. And migraines, where light, smells, or movement can trigger an attack, are another type of headache that might also be worsened by taking Zoloft.

How Does Zoloft Cause Headaches?

Zoloft is an SSRI that changes the level of serotonin in the brain. When serotonin levels change, the result for some is a migraine headache. When you take Zoloft, it blocks the reabsorption of serotonin in the brain, which is what happens when someone has a migraine.

When a headache is a side effect of Zoloft, this usually occurs when people have a history of migraines or cluster headaches. In some cases, those who don’t typically experience migraines might develop them as a result of taking this drug.

Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat depression, anxiety, and other mental health conditions. While Zoloft is generally well-tolerated, like any medication, it can cause side effects in some people. One of the possible side effects of Zoloft is headaches.

The exact mechanism by which Zoloft causes headaches is not entirely clear. However, some possible explanations include:

  1. Serotonin levels: Zoloft works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that regulates mood, appetite, and sleep. An increase in serotonin levels can cause blood vessels to constrict, which can lead to headaches.
  2. Withdrawal symptoms: If a person stops taking Zoloft abruptly, it can cause withdrawal symptoms, including headaches. This is because the brain has become accustomed to the increased levels of serotonin provided by the medication, and suddenly stopping it can disrupt the neurotransmitter balance.
  3. Dehydration: Zoloft can cause dry mouth, which can lead to dehydration. Dehydration can cause headaches.
  4. Other factors: It is also possible that headaches caused by Zoloft are related to other factors, such as stress or underlying medical conditions.

If you are experiencing headaches while taking Zoloft, it is important to talk to your doctor. They may recommend adjusting your dosage, switching to a different medication, or taking other steps to manage your symptoms. Additionally, drinking plenty of water, getting enough sleep, and practicing stress-reducing techniques such as exercise and meditation may also help alleviate headaches.

What Should You Do When You Have Sertraline-Induced Headache?

If your doctor prescribed Zoloft and you have headaches, talk to them. It could be that the drug is not the right one for you and your headache type. If it’s determined that the medication is likely causing your headaches, some tips can help prevent the side effect from worsening.

Ask your doctor if it would be best to reduce your dosage or take your medication at a different time of day.

You may also want to try taking an over-the-counter pain reliever like Tylenol (acetaminophen) as well as rest and more fluids. Whether you’ve been taking this medication for a short time or years, always speak up about anything that concerns you!

What can you take for headaches while on Zoloft?

If you are experiencing headaches while taking Zoloft, it is important to talk to your doctor before taking any over-the-counter medications for headache relief. This is because some medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can interact with Zoloft and may increase the risk of side effects.

Your doctor may recommend alternative medications for headache relief that are safe to take with Zoloft. For example, acetaminophen (Tylenol) is generally considered safe to take with SSRIs like Zoloft, although it is important to follow the recommended dosage and frequency of use.

In addition to medication, several other strategies may help alleviate headaches while taking Zoloft:

  1. Stay hydrated: Drinking plenty of water throughout the day can help prevent dehydration, which can cause headaches.
  2. Get enough sleep: Adequate sleep is essential for overall health and well-being and can help reduce the risk of headaches.
  3. Practice stress-reducing techniques: Stress can trigger headaches, so finding ways to manage stress, such as exercise, yoga, or meditation, may help.
  4. Avoid triggers: Certain foods or environmental factors, such as caffeine, alcohol, or bright lights, can trigger headaches in some people. Avoiding these triggers may help reduce the frequency and severity of headaches.

Always discuss any new symptoms or concerns with your doctor to ensure proper treatment and management. Zoloft can cause a headache. If you have type T migraine headaches, you might experience this side effect. If you experience headaches and have headaches while taking Zoloft, try Tylenol Extra Strength.

You can also take acetaminophen if they don’t interact with your medication. However, ibuprofen may increase the risk of bleeding and thus should be avoided when taking Zoloft.

Do headaches from Zoloft go away?

Zoloft headaches usually disappear after two to four weeks of use as your body gets used to Sertraline.

But if you have a headache after taking Zoloft, there are a few things you can do to get relief.

  1. Take your dose as soon as possible after you remember
  2. You can use Tynelol for the headaches if you have just started taking Zoloft
  3. Drink lots of water
  4. Take some rest or sleep
  5. Reduce your dosage by half and take the new dose for five days
  6. Stop taking Zoloft and switch to another antidepressant instead.

Why does sertraline cause headaches?

Sertraline is a type of antidepressant that falls into the SSRI drug category. It’s been proven to work as well as other SSRIs in clinical trials, and it produces fewer side effects than many other antidepressants. It’s also generally considered safe for use by pregnant women, which is good news for expecting mothers who suffer from depression.

But there is one side effect that some people experience while taking sertraline: headaches. When there’s too much serotonin in the brain this can cause confusion, diarrhea, and headaches. A medication like Zoloft could be triggering your headaches because it raises serotonin levels too much.

The medication increases the available serotonin in the brain. This happens when you start taking the medication or increase the dosage. If you have dangerously high levels of the neurotransmitter serotonin in the brain you will experience side effects such as confusion, diarrhea, and headaches.

What are the most common side effects of sertraline?

Sertraline is an antidepressant and anti-anxiety medication. Common side effects of sertraline are diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia (diminished appetite), and a decreased libido (sex drive), among others.

Some less common side effects are diaphoresis (sweating), hair loss or thinning, and xerostomia (dry mouth).

It’s important to note that not everyone who takes sertraline will experience side effects, and the severity of side effects can vary from person to person. If you are experiencing any side effects or have concerns about taking sertraline, it’s important to talk to your doctor.

Long-term side effects of antidepressants

The following graph shows the list of potential long-term side effects of Sertraline.

Long-term side effects of antidepressants like Zoloft
Long-term side effects of antidepressants

Other long-term side effects that are commonly experienced include:

  • Feelings of emptiness (25%)
  • Feeling as if they’re in a mental fog (24%)
  • Feeling as if they’re in a dream state (22%)
  • Loss of interest in sex (21%).

Side effects like these are why it’s so important to work with your doctor and talk about the benefits and risks before taking any medication. It’s important to note that Zoloft has the potential to cause serotonin syndrome.

How do you calm the side effects of sertraline?

There are several ways of calming the side effects of Zoloft. Some of the easy-to-implement methods include:

  • Take your antidepressant with food, unless your doctor expressly directed otherwise
  • Eat smaller, more frequent meals
  • Get plenty of sleep
  • Suck on sugarless hard candy
  • Drink plenty of fluids, including fresh juices and cool water
  • Talk to your doctor about a dosage change or a slow-release form of the medication
  • Take a warm bath
  • Exercises
  • Taking regular balanced meals
  • Practice deep breathing exercises

How can I minimize the side effects of SSRI?

You can minimize the side effects of SSRIs by changing the timing of doses, exercising, taking lots of fluids, eating balanced meals, taking the medication with food, Consulting your doctor about reducing the dosage, and chewing or sucking on sugarless hard candy.

SSRI medications can cause a variety of side effects, but these can often be minimized with changes in diet and exercise. You should take your medication with food, and drink plenty of fluids. If you’re experiencing dizziness or lightheadedness, avoid standing for long periods or driving.

You might also try changing the timing of your doses so that they’re closer together (every 8 hours instead of 12). This may help reduce side effects like headaches. It’s also a good idea to exercise regularly and make sure you’re eating balanced meals. That way, you’ll have more energy to cope with the symptoms!

If none of those things help, talk to your doctor about reducing the dosage. Your doctor might also recommend chewing or sucking on sugarless hard candy when you feel a headache coming on. This will distract your nerve cells from feeling pain signals and can shorten or prevent the duration of an attack.

Can antidepressants give you migraines?

Yes, due to changes in the level of serotonin that the body is used to tolerating. One of the side effects of antidepressants is a change in serotonin levels. Since migraines are often triggered by changes in serotonin, an antidepressant can give you migraines.

The change in serotonin can affect how the brain functions and may cause headaches as a result. A headache could also be due to a change in other brain chemicals that regulate moods or sleep patterns. If you take Zoloft or any other drug for depression or anxiety, at the same time, you might experience headaches as a side effect.

Antidepressants, including sertraline, have been known to cause headaches or migraines as a side effect in some individuals. However, it’s important to note that not everyone who takes antidepressants will experience this side effect.

In some cases, the headache or migraine may be a temporary side effect that goes away after a few weeks of taking the medication. However, if the headaches or migraines persist or become severe, it’s important to talk to your doctor. Your doctor may adjust your medication dose, switch you to a different antidepressant, or recommend other treatments for your headaches or migraines.

It’s also important to note that headaches and migraines can be caused by a variety of factors, including stress, poor sleep, dehydration, and certain foods or drinks. If you are experiencing headaches or migraines while taking antidepressants, it’s important to discuss your symptoms with your doctor to determine the underlying cause and develop an appropriate treatment plan.

Can I take ibuprofen with sertraline?

Using sertraline together with ibuprofen may increase the risk of bleeding, ulcers, and other problems.

Ibuprofen is a nonprescription pain and fever medication that relieves pain, inflammation, and fever. People who take sertraline should not also take ibuprofen without first talking to their doctor.

If you need to take ibuprofen, your doctor may recommend you also use another type of pain relief medication instead of sertraline. For example, if you need to treat your headache due to a tension-type headache with ibuprofen or triptan medicines like sumatriptan (Imitrex) or zolmitriptan (Zomig).

Sertraline is a prescription antidepressant that treats depression, anxiety, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), and social anxiety disorder.

Summing up

Zoloft is not the only drug that can cause headaches as a side effect. It’s just one of many drugs in this category, and there are lots of different types of headaches that might be triggered by taking this drug. You should talk to your doctor if you’re experiencing any type of headache while taking Zoloft. He or she will discuss your options with you and help you identify the best treatment for your specific needs.

FAQs

Can Zoloft cause headaches?

Zoloft could cause headaches as a side effect. This drug is used to treat depression and anxiety, but if you take it at the same time as any other medication that causes a headache, you might experience this side effect.

Why do antidepressants cause headaches?

It’s not fully understood why antidepressants cause headaches. However, some medications used to treat depression and anxiety can affect brain chemicals like serotonin. These chemicals are important for regulating moods and sleep cycles. When these changes happen, it can increase your risk of having a headache or making an existing headache worse.

Why do I get headaches when I take Zoloft?

It’s not clear why this happens, but it may be due to the medication interfering with serotonin levels in your brain. This can lead to changes in your blood vessels, which affects circulation and increases your risk of developing headaches.

What does Zoloft do in your body?

Zoloft is an antidepressant medication prescribed for the treatment of anxiety disorders, major depressive disorder, obsessive-compulsive disorder (OCD), and panic disorder. It helps restore the balance of serotonin levels in your brain by increasing serotonin production or preventing its absorption from inside the brain cells where it is produced. Serotonin is a neurotransmitter that regulates moods, so taking Zoloft can improve symptoms of depression and anxiety

Will my headache stop when I stop taking the medication?

The symptoms of withdrawal from antidepressants may include a headache, so stopping your medication suddenly may worsen the symptoms of withdrawal, including headaches from stopping Zoloft use too quickly. The best way to avoid getting a headache is by tapering off your dose gradually over time as directed by your doctor.

Image Source: Freepik

Sources:

https://www.nhs.uk/medicines/sertraline/side-effects-of-sertraline/

https://www.drugs.com/sfx/zoloft-side-effects.html

https://www.verywellmind.com/long-term-effects-of-antidepressants-4158064

https://pubmed.ncbi.nlm.nih.gov/16342007/

Dr. David Barlow

David is a well-known researcher and author in the anxiety disorders area with extensive research on their etiology, nature, and treatment. He started the site to share his real-life experiences on the management of anxiety disorders with successful diagnosis and treatment being his motivation to write or review the content on this site.