Prozac and Dry Mouth

Are you taking Prozac and finding your mouth unusually dry? You’re not alone—like most antidepressants, Prozac can cause dry mouth, but simple solutions can help you stay comfortable and maintain your oral health. Dry mouth, or xerostomia, occurs when the salivary glands don’t produce enough saliva, leading to a parched feeling in the mouth. This can be uncomfortable and may affect your oral health.

If you’re experiencing dry mouth while taking Prozac, there are several effective solutions to alleviate the discomfort:

  • Sip water regularly throughout the day to keep your mouth moist.
  • Suck on ice chips to stimulate saliva production.
  • Chew sugarless gum or suck on sugarless hard candy to help increase saliva flow.
  • Breathe through your nose instead of your mouth to prevent further dryness.
  • Maintain good oral hygiene by brushing your teeth twice a day, flossing daily, and visiting your dentist regularly.
  • Steer clear of tobacco, alcohol, and caffeinated drinks, as they can further dry out your mouth.

By incorporating these strategies, you can manage dry mouth symptoms and maintain your oral health while continuing your Prozac treatment.


Does Prozac cause dry mouth?

Prozac can cause dry mouth, a common side effect experienced with many antidepressants. The other common Prozac side effects include insomnia, nausea, headache, drowsiness, and diarrhea. This occurs when the medication reduces saliva production, leading to a parched feeling. To manage this, regularly sipping water, chewing sugarless gum, or sucking on sugarless candy can help keep your mouth moist. Moreover, these common symptoms disappear after a few weeks as the body adjusts to the medication.

In addition, excessive thirst is a common side effect that was experienced by children taking Prozac for depression or anxiety. This condition, known as xerostomia, occurs because the medication interferes with the salivary glands’ ability to produce adequate saliva, resulting in a persistent dry sensation in the mouth.

Managing a dry mouth involves several practical steps: frequently sipping water can help maintain hydration, while chewing sugarless gum or sucking on sugarless candies can stimulate saliva production and keep the mouth moist.

Additionally, it’s important to avoid substances that can worsen dry mouth, such as tobacco, alcohol, and caffeinated beverages. Maintaining good oral hygiene by brushing and flossing regularly and visiting the dentist can also help mitigate the effects of dry mouth and preserve oral health.

Does Prozac make you thirsty or dehydrated?

Prozac (fluoxetine) can make you feel thirsty, especially in children. Children between the ages of 10 and 17 who take Prozac often experience many of the same side effects as adults, but studies have shown that excessive thirst is a side effect reported in children that wasn’t commonly seen in adults. Additionally, children may face a higher risk of suicidal thoughts or behaviors when taking this medication.

Prozac (fluoxetine) does not directly cause dehydration, but it can lead to dry mouth and, in some cases, gastrointestinal side effects like diarrhea, which can contribute to dehydration if not managed properly.

To prevent dehydration, take fluoxetine in the morning and drink plenty of water or other fluids throughout the day. Watch for signs of dehydration, such as peeing less frequently or having dark, strong-smelling urine, and consult a pharmacist or doctor before taking any additional medication to treat diarrhea.

Managing Prozac dry mouth

To manage dry mouth caused by Prozac, consider discussing over-the-counter or prescription treatments with your doctor or dentist. If dry mouth persists despite other remedies like sipping water and chewing sugarless gum, talk to your doctor about the possibility of reducing the dosage of your antidepressant and weigh the pros and cons of this adjustment.

  • Hydration: Increase your water intake throughout the day to keep your mouth moist. Sipping water regularly can help alleviate dryness.
  • Sugarless Products: Chew sugarless gum or suck on sugarless candies to stimulate saliva production and maintain moisture in your mouth.
  • Moisturizing Mouthwash: Use a moisturizing mouthwash specifically designed for dry mouth. These mouthwashes can provide relief and help keep your mouth hydrated.
  • Saliva Substitutes: Consider using over-the-counter saliva substitutes or artificial saliva products. These can mimic the natural lubricating properties of saliva and ease dry mouth symptoms.
  • Humidifier: Use a humidifier in your home, especially at night, to add moisture to the air. This can be particularly helpful if dry mouth is worse during sleep.
  • Consultation with Healthcare Provider: Talk to your doctor or dentist about over-the-counter or prescription medications specifically formulated to address dry mouth. They can recommend products or medications that may be suitable for your situation.
  • Dosage Adjustment: If dry mouth persists and is extremely bothersome, discuss with your doctor the possibility of adjusting the dosage of your antidepressant. Lowering the dosage may reduce the severity of dry mouth while still providing effective treatment for your condition. However, always weigh the pros and cons of dosage adjustments with your healthcare provider.

Genetic variations

Genetic variations can significantly impact the effectiveness and potential side effects of specific antidepressants. Studies suggest that your genetic makeup may influence whether a particular antidepressant will be effective for you and whether you’re predisposed to certain side effects.

While some locations offer limited genetic testing to assist in choosing antidepressants, such testing isn’t yet standard practice and may not always be covered by insurance. Ongoing research aims to identify the best antidepressant options based on genetic factors, but genetic testing should complement, not replace, comprehensive psychiatric evaluations and clinical decision-making.


Dry mouth is a common side effect associated with Prozac and many other antidepressants. While it can be uncomfortable, there are various strategies to manage dry mouth effectively, such as staying hydrated, using sugarless products, and considering medication adjustments under the guidance of a healthcare provider.

Additionally, ongoing research on genetic variations and antidepressant response may offer personalized treatment options in the future. It’s essential to discuss any concerns or persistent symptoms with your healthcare provider to ensure optimal management of dry mouth and overall well-being during antidepressant treatment.

Dr. David Barlow

David is a well-known researcher and author in the anxiety disorders area with extensive research on their etiology, nature, and treatment. He started the site to share his real-life experiences on the management of anxiety disorders with successful diagnosis and treatment being his motivation to write or review the content on this site.